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_collapsible-up_1grw8_1{0%{max-height:var(--radix-collapsible-content-height)}to{max-height:0}}._trigger_1grw8_20{cursor:pointer;display:block;appearance:none;border:none;background:transparent;color:inherit}._content_1grw8_29{overflow:hidden}._content_1grw8_29[data-state=open]{animation:_collapsible-down_1grw8_1 var(--animation-duration-fast) ease-out}._content_1grw8_29[data-state=closed]{animation:_collapsible-up_1grw8_1 var(--animation-duration-fast) ease-out}}._reader_1cv94_1._reader_1cv94_1{grid-template-columns:minmax(0,1fr);gap:24px;max-width:1440px;margin-inline:auto}._reader_1cv94_1 ._desktopNav_1cv94_2{display:none}._reader_1cv94_1 ._mobileNav_1cv94_3{display:block;margin-top:20px}._reader_1cv94_1 ._mobileLinks_1cv94_4{max-height:min(55dvh,30rem);overflow-y:auto}._reader_1cv94_1 ._article_1cv94_5{max-width:none}._reader_1cv94_1 ._article_1cv94_5 p,._reader_1cv94_1 ._article_1cv94_5 li{font-size:var(--reader-font-size,18px);line-height:1.85}._reader_1cv94_1 ._article_1cv94_5 p{max-width:80ch;margin-block:1em}._reader_1cv94_1 ._header_1cv94_8 h1{font-weight:600;line-height:1.25}._reader_1cv94_1 ._section_1cv94_9 h3,._reader_1cv94_1 ._clinicalGroup_1cv94_9>h3{font-weight:700;font-size:clamp(1.35rem,2vw,1.7rem);line-height:1.4}._reader_1cv94_1 ._section_1cv94_9 h4{font-weight:700;font-size:clamp(1.15rem,1.6vw,1.35rem);line-height:1.45}._reader_1cv94_1 ._article_1cv94_5 td,._reader_1cv94_1 ._article_1cv94_5 th{font-size:max(16px,calc(var(--reader-font-size,18px) - 2px));line-height:1.7}._reader_1cv94_1 [tabindex="-1"]{scroll-margin-top:100px}._reader_1cv94_1 ._referenceToggle_1cv94_13{background:var(--surface);color:var(--ink);border-color:var(--border);border-radius:10px}._reader_1cv94_1 ._article_1cv94_5 ._meta_1cv94_14,._reader_1cv94_1 ._article_1cv94_5 ._notice_1cv94_14,._reader_1cv94_1 ._article_1cv94_5 ._references_1cv94_14 p{font-size:15px;line-height:1.75}._reader_1cv94_1 ._mobileTrigger_1cv94_15{min-height:52px;font-size:1.05rem;letter-spacing:.01em}@media(min-width:1200px){._reader_1cv94_1._reader_1cv94_1{grid-template-columns:210px minmax(0,1fr);gap:clamp(24px,3vw,48px)}._reader_1cv94_1 ._desktopNav_1cv94_2{display:flex;top:90px;max-height:calc(100dvh - 110px)}._reader_1cv94_1 ._desktopNav_1cv94_2 a{padding-block:8px;min-height:44px}._reader_1cv94_1 ._mobileNav_1cv94_3{display:none}}[data-reading-focus] ._reader_1cv94_1._reader_1cv94_1{grid-template-columns:minmax(0,1fr);max-width:1200px}[data-reading-focus] ._reader_1cv94_1 ._desktopNav_1cv94_2{display:none}[data-reading-focus] ._reader_1cv94_1 ._mobileNav_1cv94_3{display:block}@media(max-width:600px){._reader_1cv94_1 ._article_1cv94_5 p,._reader_1cv94_1 ._article_1cv94_5 li{text-align:start;text-align-last:auto;hyphens:none}._reader_1cv94_1 ._article_1cv94_5 p{line-height:1.8}._reader_1cv94_1 ._mobileLinks_1cv94_4 a{font-size:1rem;text-transform:none}}@media print{._reader_1cv94_1 ._desktopNav_1cv94_2,._reader_1cv94_1 ._mobileNav_1cv94_3{display:none}._reader_1cv94_1._reader_1cv94_1{display:block}._reader_1cv94_1 ._article_1cv94_5 p{max-width:none}}._reader_1cv94_1{display:grid;grid-template-columns:minmax(180px,220px) minmax(0,1fr);gap:var(--spacing-12);position:relative;min-width:0;color:var(--foreground);font-family:var(--font-family-base);line-height:1.6}._reader_1cv94_1 *,._reader_1cv94_1 *:before,._reader_1cv94_1 *:after{box-sizing:border-box}._reader_1cv94_1 :where(a:not([data-button])){color:var(--primary);text-underline-offset:3px}._reader_1cv94_1 a:hover{text-decoration:underline}._reader_1cv94_1 a:focus-visible,._reader_1cv94_1 button:focus-visible,._reader_1cv94_1 [tabindex="-1"]:focus-visible{outline:2px solid var(--primary);outline-offset:4px}._reader_1cv94_1 [tabindex="-1"]{scroll-margin-top:var(--spacing-8)}._skip_1cv94_40{position:absolute;left:0;top:0;transform:translateY(-200%);opacity:0;padding:var(--spacing-3);background:var(--card)}._skip_1cv94_40:focus{transform:none;opacity:1;z-index:2}._desktopNav_1cv94_2{position:sticky;top:var(--spacing-6);align-self:start;display:flex;flex-direction:column;gap:var(--spacing-3);max-height:calc(100dvh - var(--spacing-12));overflow-y:auto;min-width:0;padding:var(--spacing-2) var(--spacing-6) var(--spacing-2) var(--spacing-1);border-right:1px solid var(--border);font-size:14px}._desktopNav_1cv94_2 strong{color:var(--ink);font-size:14px;margin-bottom:var(--spacing-2)}._desktopNav_1cv94_2 a,._mobileLinks_1cv94_4 a{display:block;color:var(--muted-foreground);overflow-wrap:anywhere;text-decoration:none}._desktopNav_1cv94_2 a[aria-current],._mobileLinks_1cv94_4 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0}._layerNote_1cv94_68{font-size:14px;line-height:1.7;color:var(--muted-foreground);margin:var(--spacing-3) 0 0}._body_1cv94_69{min-width:0}._generalLayer_1cv94_70,._professionalLayer_1cv94_70{margin-top:var(--spacing-8)}._professionalLayer_1cv94_70{padding-top:var(--spacing-6);border-top:1px solid var(--border)}._professionalLayer_1cv94_70>section+section{margin-top:var(--spacing-12)}._layerHeading_1cv94_73{display:flex;align-items:baseline;gap:var(--spacing-3)}._layerHeading_1cv94_73>span{color:var(--primary);font-size:14px;font-family:var(--font-family-monospace)}._layerHeading_1cv94_73 h2,._references_1cv94_14 h2{font-family:var(--font-family-display);font-size:29px;line-height:1.3;font-weight:500;color:var(--ink);margin:0}._section_1cv94_9{padding-top:var(--spacing-6);margin-top:var(--spacing-4);min-width:0}._section_1cv94_9+._section_1cv94_9{border-top:1px solid var(--border)}._section_1cv94_9 h3{font-family:var(--font-family-display);font-size:24px;line-height:1.35;font-weight:500;color:var(--ink);margin:0 0 var(--spacing-3)}._section_1cv94_9 p{font-size:16px;line-height:1.85;margin:var(--spacing-3) 0;white-space:pre-line}._cites_1cv94_80{display:flex;flex-wrap:wrap;align-items:baseline;gap:var(--spacing-2);font-size:14px;line-height:1.5}._cites_1cv94_80>span{color:var(--muted-foreground)}._cites_1cv94_80 a{display:inline-flex;align-items:center;min-height:28px;padding:var(--spacing-1)}._references_1cv94_14{margin-top:var(--spacing-12);border-top:1px solid var(--border);padding-top:var(--spacing-6)}._references_1cv94_14 ol{margin:var(--spacing-4) 0 0;padding-left:var(--spacing-6)}._references_1cv94_14 li{padding:var(--spacing-3) 0;font-size:14px;line-height:1.7}._references_1cv94_14 p{font-size:14px;color:var(--muted-foreground);margin:var(--spacing-1) 0 0}._notice_1cv94_14,._empty_1cv94_87{font-size:14px;line-height:1.8;background:var(--warm-note);padding:var(--spacing-4);margin-top:var(--spacing-8);border-radius:var(--radius-sm)}._mobileNav_1cv94_3{display:none}._reader_1cv94_1 ._mobileTrigger_1cv94_15{display:grid;grid-template-columns:1.5rem minmax(0,1fr) 1.5rem;align-items:center;gap:var(--spacing-3);width:100%;min-width:0;min-height:64px;height:auto;padding:var(--spacing-4) var(--spacing-4);border:1px solid var(--border);border-radius:var(--radius-md);background:var(--surface);color:var(--ink);box-shadow:var(--shadow);font-family:var(--font-family-base);font-size:1.25rem;font-weight:700;line-height:1.4;letter-spacing:.035em;text-align:center;text-align-last:center;white-space:normal}._mobileTriggerLabel_1cv94_114{display:block;min-width:0;overflow-wrap:anywhere}._reader_1cv94_1 ._mobileTrigger_1cv94_15>svg{width:1.25rem;height:1.25rem;justify-self:center;color:var(--primary)}._reader_1cv94_1 ._mobileTrigger_1cv94_15:hover,._reader_1cv94_1 ._mobileTrigger_1cv94_15[data-state=open]{background:var(--muted);border-color:var(--primary)}._reader_1cv94_1 ._mobileTrigger_1cv94_15:focus-visible{outline:3px solid var(--primary);outline-offset:4px}._mobileTriggerChevron_1cv94_118{transition:transform var(--animation-duration-fast) ease}._mobileTrigger_1cv94_15[data-state=open] ._mobileTriggerChevron_1cv94_118{transform:rotate(180deg)}._mobileLinks_1cv94_4{display:flex;flex-direction:column;gap:var(--spacing-2);min-width:0;padding:var(--spacing-3);margin-top:var(--spacing-2);border:1px solid var(--border);border-radius:var(--radius-md);background:var(--card);font-size:1.125rem;line-height:1.55;overscroll-behavior:contain}._mobileLinks_1cv94_4>*{flex-shrink:0}._reader_1cv94_1 ._mobileLinks_1cv94_4 a{display:flex;align-items:center;justify-content:center;width:100%;min-width:0;min-height:44px;padding:10px var(--spacing-3);border-radius:var(--radius-sm);color:var(--foreground);font-size:1.125rem;font-weight:600;text-align:center;text-align-last:center;text-transform:uppercase;white-space:normal;overflow-wrap:anywhere;word-break:normal;hyphens:none}._reader_1cv94_1 ._mobileLinks_1cv94_4 a:hover{background:var(--surface);color:var(--primary)}._reader_1cv94_1 ._mobileLinks_1cv94_4 a[aria-current]{background:var(--secondary);color:var(--secondary-foreground);font-weight:600;text-decoration:underline}._reader_1cv94_1 ._mobileLinks_1cv94_4 a:focus-visible{outline:2px solid var(--primary);outline-offset:2px}._mobileLinks_1cv94_4 ._navGroup_1cv94_59>span{display:block;padding:var(--spacing-2) var(--spacing-3);color:var(--primary);font-size:1.125rem;font-weight:700;letter-spacing:.04em;text-align:center;text-align-last:center;text-transform:uppercase}._mobileLinks_1cv94_4 ._navGroup_1cv94_59 ul{min-width:0;margin:var(--spacing-1) 0 0;padding:0;border-left:0}@media(max-width:850px){._reader_1cv94_1{grid-template-columns:minmax(0,1fr);gap:0}._desktopNav_1cv94_2{display:none}._article_1cv94_5{max-width:none}._mobileNav_1cv94_3{display:block;min-width:0;margin-top:var(--spacing-6)}._mobileLinks_1cv94_4{max-height:min(60dvh,32rem);overflow-y:auto}._header_1cv94_8 h1{font-size:clamp(2rem,8vw,2.5rem)}._summary_1cv94_67{font-size:20px}._section_1cv94_9 p{font-size:16px}._layerHeading_1cv94_73 h2,._references_1cv94_14 h2{font-size:26px}._section_1cv94_9 h3{font-size:23px}._cites_1cv94_80 a{min-width:32px;min-height:44px}}@media(prefers-reduced-motion:reduce){._reader_1cv94_1 *,._reader_1cv94_1 *:before,._reader_1cv94_1 *:after{scroll-behavior:auto;animation:none!important;transition:none!important}}._clinicalGroup_1cv94_9{margin-top:var(--spacing-8);padding-top:var(--spacing-6);border-top:1px solid 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h4,._reader_1cv94_1 h5,._reader_1cv94_1 h6,._reader_1cv94_1 thead th,._reader_1cv94_1 button{text-align:center;text-align-last:center}._reader_1cv94_1 h1,._reader_1cv94_1 h2,._reader_1cv94_1 h3,._reader_1cv94_1 h4,._reader_1cv94_1 h5,._reader_1cv94_1 h6{text-transform:uppercase}._reader_1cv94_1 ._desktopNav_1cv94_2 li{text-align:start;text-align-last:auto;hyphens:none}._reader_1cv94_1 ._mobileLinks_1cv94_4 li{text-align:center;text-align-last:center;hyphens:none}._header_1cv94_8>._eyebrow_1cv94_65{display:block;text-align:center}._meta_1cv94_14{text-align:center}._summary_1cv94_67{font-family:var(--font-family-base);font-size:17px;font-weight:400;line-height:1.85}@media(max-width:480px){._reader_1cv94_1 p,._reader_1cv94_1 td,._reader_1cv94_1 li{hyphenate-limit-chars:8 3 3;hyphenate-limit-lines:2}._summary_1cv94_67{font-size:16px}}._referenceToggle_1cv94_13{display:block;width:100%;max-width:100%;list-style:none;margin:.83em 0;border:1px solid #D4E1E8;border-radius:6px;padding:.8rem 1rem;background:#eef2f5;color:#17324d;font-family:IBM Plex Sans,sans-serif;font-weight:600;font-size:clamp(1rem,1.5vw,1.2rem);line-height:1.45;text-align:center;text-align-last:center;cursor:pointer}._referenceToggle_1cv94_13::-webkit-details-marker{display:none}._referenceToggle_1cv94_13>h2{margin:0;border:0;padding:0;border-radius:0;background:transparent;color:inherit;font:inherit;text-align:center}._referenceToggle_1cv94_13>._referenceToggleHint_1cv94_210{display:block;margin-top:4px;font:400 14px/1.5 system-ui,sans-serif;text-align:center}._referenceToggle_1cv94_13:focus-visible{outline:3px solid #c99217;outline-offset:4px}@media print{._referenceDisclosure_1cv94_212::details-content{display:block;content-visibility:visible}._referenceContent_1cv94_212{display:block!important}}._reader_1cv94_1 :where(a:not([data-button])){color:var(--reading-link,var(--primary))}@container (max-width:600px){._reader_1cv94_1{grid-template-columns:minmax(0,1fr);gap:0}._desktopNav_1cv94_2{display:none}._mobileNav_1cv94_3{display:block}._article_1cv94_5{max-width:none}}@container (max-width:200px){._reader_1cv94_1 ._mobileTrigger_1cv94_15{grid-template-columns:1.25rem minmax(0,1fr) 1.25rem;gap:6px;padding:8px}}